Expert profile
Dr. Matt Kaeberlein
Professor and longevity researcher
Biology of aging and healthspan
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About the expert
Focus: Biology of aging, rapamycin, and healthspan
Matt Kaeberlein is a professor and longtime leader in aging research. He studies the biology of healthspan in humans and animals. His work looks at drugs like rapamycin and how to separate real findings from hype.
Expert discussions with Dr. Matt Kaeberlein
Could rapamycin actually slow human aging?
Rapamycin is widely considered one of the most promising candidate drugs for slowing biological aging, but it has not yet been proven to do so in humans. In mice it reliably extends lifespan and improves or restores some age-related declines in heart, immune, and other functions, even when started in middle age. Early human data hint at benefits for immunity, brain blood flow, and inflammation, but large trials are missing, and any use for aging is off-label and experimental.